Abstract: Objective To analyze the clinicopathological features and ultrasonic manifestations of male breast neoplasms. Methods The clinical data of 28 male patients with breast neoplasms in Subei People's Hospital in Jiangsu Province was retrospectively analyzed. Results Out of 28 male patients with breast neoplasms, fifteen patients visited doctors after developing symptoms of nipples discharge, and twelve patients had a duration of more than 1 year. At the same time, four of them did not complete further treatment. Out of nineteen male breast cancer(MBC)patients, the following ultrasonic manifestations were noticed: fifteen cases(78.9%)showed hypo echoic mass, three cases(15.8%)showed calcification and six cases(31.6%)showed increased focal vascularity. The primary site of MBC patients was located in the central portion in 16 cases(84.2%). The primary site of MBC group and non-MBC group showed significant difference(P<0.05). Conclusion Male patients are likely to reluctant to see a doctor early and have poor compliance to treatment. The primary site of MBC is mostly located in the central portion and manifestations of ultrasound images include hypo-echoic mass, calcification and increased focal vascularity, which could be helpful for differential diagnosis between benign and malignant male breast neoplasms.