Objective  To investigate the effects of hydrosalpinx, salpingitis, and tubal occlusionon on clinical outcomes of in vitro fertilization embryo transfer (IVF-ET).

  Methods  A retrospective analysis was performed for data of 419 infertility patients caused by tubal diseases who received IVF-ET for the first time in the reproductive medicine center of Xuzhou Central Hospital. They were divided into salpingitis group (213 cases, group A), hydrosalpinx group (81 cases, group B) and tubal occlusion group (125 cases, group C). The number of oocytes retrieved, fertilization rate, cleavage rate, high quality embryo rate, implantation rate, clinical pregnancy rate, ectopic pregnancy rate and live birth rate were compared among the three groups.

  Results  The implantation rate and clinical pregnancy rate in the group C were significantly higher than those in groups A and B, the ectopic pregnancy rate in group B was significantly higher than that in groups A and C, the rate of D3 high-quality embryos in the group A was significantly lower than that in groups B and C, and live birth rates in groups A and B were significantly higner than those in groups(P < 0.05).

  Conclusion  Salpingitis has a negative effect on the success rate of IVF-ET, so it is necessary to treat salpingitis before IVF-ET.