Abstract: Objective To analyze the effect of alprostadil combined with nimodipine on inflammatory factor levels in patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage(aSAH). Methods A total of 143 patients were divided into control group and observation group. Patients in the control group(n=71)were treated with alprostadil, while patients in the observation group(n=72)were treated with alprostadil and nimodipine. The levels of interleukin-6(IL-6), interleukin-8(IL-8), highsensitive C-reactive protein(hs-CRP), and tumor necrosis factor-α(TNF-α), therapeutic effects, adverse reactions, and cognitive functions in the two groups were compared. Results After treatment, the levels of inflammatory factors and the total incidence of adverse reactions in the observation group were significantly lower than those in the control group, and the total effective rate and Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)score in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Alprostadil combined with nimodipine is safe and effective, which can effectively reduce the levels of inflammatory factors as well as the incidence of adverse reactions, and improve cognitive function of the patients with cerebral vasospasm after aSAH.