Abstract: Objective To observe the effect of nasopharyngeal airway tube in prevention of respiratory complications in stroke patients with analgesia and sedation. Methods A total of 64 patients were randomly divided into control group and observation group, with 32 caess in each group. The control group was given nasal catheter oxygen inhalation therapy, the observation group was placed nasopharyngeal airway tube oxygen inhalation. General clinical data, respiratory indicators, endotracheal intubation or tracheotomy rate, clinical pulmonary infection score, and number of cases with pharyngeal edema were compared in the two groups. Results After nasopharyngeal ventilation tube was placed for 10 and 30 min, the respiratory rate and arterial partial pressure of carbon dioxide in the observation group were lower than those in the control group(P<0.05). The rate of endotracheal intubation or tracheotomy in the observation group was lower than that in the control group, but the difference was not statistically significant(P>0.05); there was statistically significant differences in lung infection score between the two groups(P<0.05); there was no significant difference in the number of cases with pharyngeal edema between the two groups(P>0.05). Conclusion Nasopharyngeal airway tube can improve the ventilation function of stroke patients with analgesia and sedation, and reduce the incidence of lung infection.