Abstract: Objective To explore the clinical value of aspirin combined with clopidogrel in the treatment of cerebral thrombosis. Methods A total of 74 patients with cerebral thrombosis were selected and divided into control group and study group according to random throw method. The control group(n=37)was given aspirin, and the study group(n=37)was given aspirin combined with clopidogrel, and the treatment effects were compared between the two groups. Results The total effective rate in the study group was 91.89%, which was significantly higher than 72.97%in the control group(P<0.05). There was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)score between the two groups before treatment(P>0.05). The NIHSS scores at 7 and 14 d of the study group were lower than that of the control group(P<0.05); plasma viscosity, high-cut whole-blood viscosity, low-cut whole-blood viscosity, platelet adhesion rate activated partial thromboplastin time and D-dimer showed no significant differences(P>0.05), and were better in the study group than those in the control group after treatment(P<0.05); the incidence of adverse reactions in the study group was 18.92%, and 13.51%in the control group, but there was no significant difference(P>0.05). Conclusion Combined use of aspirin and clopidogrel in the clinical treatment of cerebral thrombosis is of high value, which can improve hemorheology indexes and coagulation function indexes, relieve the degree of nerve function defect, and enhance clinical efficacy.