Abstract: Objective To observe the effect of nursing intervention based on analytic hierarchy process in prevention of phlebothrombosis of lower limbs after renal tumor resection. Methods Clinical materials of 80 patients with renal tumor resection from October 2017 to October 2019 were analyzed retrospectively. According to the application time of nursing intervention based on analytic hierarchy process, the patients treated with routine nursing intervention from October 2017 to September 2018 were selected as control group(n=34), and the patients treated with nursing intervention based on analytic hierarchy process from October 2018 to October 2019 were selected as study group(n=46). Rehabilitation related indexes, coagulation and fibrinolysis indexes after intervention, quality of life, incidence of complications and excellent rate of nursing were compared between the two groups. Results The time to anal exhaustion, infusion time, time to first activity and hospitalization time of the study group were significantly shorter than those of the control group, and the hospitalization expense was signifiantly less than that of the control group(P<0.05). After the intervention, prothrombin time(PT), D-dimer, partial thromboplastin time(APTT), plasma tissue plasminogen activator antigen(TPA-Ag)in the study group were significantly lower than those in the control group, and the tissue-type plasminogen activator inhibitor(PAI)was significantly higher than that in the control group(P<0.05). After intervention, the scores of environment, physiology, independence, psychological state, mental support, social relationship and total score in both groups increased significantly, and the - scores of environment, physiological condition, independent state, psychological state, mental support, social relationship score and total score in the study group were significantly higher than those in the control group(P<0.05). The incidence rates of lower limbs swelling or pain, venous thrombosis of lower limbs, pulmonary embolism and other complications in the study group were significantly lower than those in the control group(P<0.05). The excellent rate of nursing in the study group was 97.83%, which was significantly higher than 67.65% in the control group(P<0.05). Conclusion Nursing intervention based on analytic hierarchy process can effectively shorten the recovery time of patients with renal tumor resection, improve the quality of life of patients, and prevent phlebothrombosis of lower limbs.