Abstract: Objective To analyze the correlations between the ratio of mean platelet volume to platelet count(MPR), the ratio of mean platelet distribution width to platelet count(PPR)and disease activity in patients with gout. Methods Totally 155 patients with gout were selected, including 82 gout patients in acute phase and 73 gout patients in intermittent phase. Another 108 healthy people were selected as control group. Routine blood test was performed in all patients. The mean platelet volume(MPV), platelet distribution width(PDW), platelet(PLT), erythrocyte sedimentation rate(ESR), C reactive protein(CRP)and serum uric acid(SUA)were recorded. Results MPR and PPR levels of the acute gout group were significantly lower than those of the control group and the intermittent gout group(P<0.05), and MPR level of the intermittent gout group was significantly higher than that of control group(P<0.05). There were significant differences in MPR and PPR before and after treatment in 75 cases with 6 months of formal treatment(P<0.05). MPV, PDW, MPV/PDW, MPR, PPR were negatively correlated with ESR in patients with acute phase of gout(P<0.05 or P<0.01), MPR and PPR were significantly negatively correlated with CRP(P<0.05), and there were no correlations between MPV, PDW, MPV/PDW, MPR, PPR and SUA(P>0.05). Receiver operating characteristic(ROC)curve was drawn on the basis of MPR and PPR in gout patients in acute phase, the values of area under the curve(AUC)of MPR and PPR were - 0.720(95% CI was 0.641 to 0.798, P=0.001)and 0.699(95% CI was 0.617 to 0.780, P=0.001)respectively. When the Youden index of MPR was 0.365, the sensitivity was 87.7% and the specificity was 51.2%. When the Youden index of PPR was 0.317, the sensitivity was 89.0% and the specificity was 57.3%. Conclusion MPR and PPR have certain clinical application value in evaluating disease activity and treatment condition of gout patients.