Abstract: Chronic obstructive pulmonary disease (COPD) is a complex and highly heterogeneous systemic disease. As one of the multiple complications of COPD, sarcopenia can accelerate the disease process, increase the disability rate and all-cause mortality. In recent years, studies have founded that the risk factors of COPD with sarcopenia were limited activity, malnutrition, fat deposition and so on. Combined with pulmonary function related indicators and muscle measurement techniques, the survival and mortality rates of hospitalized patients can be predicted more accurately. On this basis, individualized intervention is of great clinical significance to improve the outcome and prognosis of the disease. This article reviewed the risk factors, diagnosis, intervention and treatment of COPD and sarcopenia.