Abstract: Objective To investigate the effectiveness and safety of continuous subcutaneous insulin infusion in the treatment of gestational diabetes. Methods A total of 80 patients with gestational diabetes were divided into control group and study group. The control group was treated with multiple subcutaneous injections of insulin, while the study group was treated with continuous subcutaneous infusion of insulin. The efficacy and safety of the two groups were compared. Results The insulin dosage and blood glucose drift of the study group were smaller than those of the control group, and the time to reach the standard value of blood glucose was earlier than that in the control group, and the differences were significant(P<0.05). The levels of fasting blood glucose(FPG), 2 h postprandial blood glucose(2hPG), hemoglobin(HbAlc), serum homocysteine(Hcy), and serum cystatin C(Cys-C)showed no significant differences before treatment(P>0.05). After treatment, the blood glucose indexes and serum indexes levels of the study group were significantly low than those in the control group(P<0.05); the incidence of adverse events such as premature delivery, cesarean section, pregnancy-induced hypertension, polyhydramnios, and neonatal asphyxia in the study group was lower than that in the control group(P<0.05). Conclusion Continuous subcutaneous insulin infusion therapy in patients with gestational diabetes has significant results and higher safety.