Objective  To investigate the efficacy of sacubitril/valsartan and perindopril in improving ventricular remodeling in patients with chronic heart failure.

  Methods  A total of 115 heart failure patients were divided into group A (n=84) and group B (n=71). The types of heart failure in the two groups were heart failure with reduced ejection fraction(HFrEF), heart failure with mid-range ejection fraction (HFmrEF), and heart failure preserved ejection fraction (HFpEF). On the basis of conventional medication, sacubitril/valsartan was added to the group A, and perindopril was added to the group B. Echocardiographic related indexes of two groups before and after treatment were analyzed and compared.

  Results  The values of left ventricular ejection fraction (LVEF) in the two groups were significantly higher than those before treatment (P < 0.05). After 6 months of treatment, the values of LVEF in patients with HFrEF and HfmrEF types of the group A were significantly higher than those in the group B (P < 0.05). Left ventricular end diastolic dimension (LVEDd), left atrial diameter (LA) and left ventricular mass index (LVMI) in the two groups were significantly decreased than those before treatment (P < 0.05).

  Conclusion  Both sacubitril/valsartan and perindopril can improve left ventricular remodeling in patients with different types of chronic heart failure.