Abstract: Objective To analyze the influence of systemic cardiopulmonary rehabilitation nursing on cardiopulmonary function and quality of life in patients with coronary heart disease. Methods Totally 124 patients with coronary heart disease treated in our hospital from January 2019 to January 2020 were selected as research objects, and they were divided into control group(n=58)and observation group(n=66)according to different rehabilitation nursing program. Patients in the control group were treated with routine nursing program, while patients in the observation group were treated with systematic cardiopulmonary rehabilitation nursing intervention. Cardiopulmonary function indexes ［anaerobic threshold(AT), peak oxygen pulse, peak oxygen uptake, equivalent slope of carbon dioxide ventilation(V_E/V_CO2), 6-minute walk test(6MWD)］, quality of life and nursing satisfaction degree were compared between the two groups. Results After intervention, the AT, peak oxygen pulse, peak oxygen uptake and 6WMD of the observation group were significantly higher than those of the control group, and V_E/V_CO2 was significantly lower than that of the control group(P<0.01). After the intervention, the score of each dimension of quality of life in both groups significantly improved when compared with that before treatment(P<0.01), and the scores of physiological function, social function, vitality, emotional function, mental health and general health of the observation group were significantly higher than those of the control group(P<0.01). The total satisfaction degree of the observation group was 98.48%, which was significantly higher than 86.20% of the control group(P<0.01). Conclusion Systemic cardiopulmonary rehabilitation nursing intervention is safe and effective in treatment of patients with coronary heart disease during rehabilitation period, - which can improve cardiopulmonary function, exercise endurance and quality oflife.