丁苯酞序贯治疗对进展性缺血性脑卒中的效果

杨友玲; 夏彬

doi:10.7619/jcmp.20201403

丁苯酞序贯治疗对进展性缺血性脑卒中的效果

杨友玲,
夏彬

Effect of sequential treatment of progressive ischemic stroke by butylphthalide

摘要

摘要:
目的观察丁苯酞序贯治疗进展性缺血性脑卒中(PIS)的效果。
方法将102例PIS患者随机分为对照组与观察组，每组51例。对照组给予基础治疗，观察组给予丁苯酞序贯治疗联合基础治疗。比较2组治疗前后神经功能缺损评分量表(NIHSS)、日常生活能力(ADL)及血浆巯基丙酮酸硫基转移酶(3-MST)、β淀粉样蛋白42(Aβ₄₂)表达水平和不良反应发生情况。
结果 2组NIHSS评分均低于治疗前，且观察组低于对照组，差异有统计学意义(P < 0.05)。2组ADL评分均高于治疗前，且观察组高于对照组，差异有统计学意义(P < 0.05)。观察组血浆3-MST水平高于对照组，血浆Aβ₄₂水平低于对照组，差异有统计学意义(P < 0.05)。
结论丁苯酞序贯治疗可显著改善PIS患者的神经功能障碍，提高其日常生活能力，安全性良好。

Abstract:
Objective To observe the effect of sequential butylphthalide therapy on progressive ischemic stroke (PIS).
Methods A total of 102 patients with PIS were randomly divided into control group and observation group, with 51 patients in each group. The control group was given basic treatment, and the observation group was given sequential butylphthalide treatment combined with basic treatment. Neurological deficit score (NIHSS), ability of daily living (ADL), plasma 3-mercaptopyruvate sulfurtransferase (3-MST) and β-amyloid peptide 42 (Aβ₄₂) expression levels as well as the incidence of ADR were compared between two groups before and after treatment.
Results The NIHSS scores in two groups were significantly lower than before treatment, and observation group was significantly lower than that in the control group (P < 0.05). The ADL scores in two groups were significantly higher than before treatment, and observation group was significantly higher than that in the control group (P < 0.05). The plasma 3-MST level of observation group was significantly higher than that in the control group, and the plasma Aβ₄₂ level of observation group was significantly lower than that in the control group (P < 0.05).
Conclusion Sequential treatment with butylphthalide can significantly improve the neurological dysfunction of patients with PIS, improve the ability of daily living, and has good safety.

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