Abstract: Objective To explone the value of combined detection of blood C reactive protein(CRP), uric acid(UA), α₁-microglobulin(α₁-MG)and urine α₁-MG in diagnosis of early renal damage in elderly patients with essential hypertension. Methods A total of 80 elderly patients with essential hypertension were selected, and were divided into early renal injury group(n=37)and simple hypertension group(n=43)according to the urine α₁-MG test results. Another 38 healthy patients without hypertension were selected as control group. Renal function indexes were compared, correlation between urine α₁-MG and renal function was analyzed, and diagnostic efficacy of different indicators were compared. Results Urine α₁-MG, blood CRP, blood UA, and blood α₁-MG in the early renal injury group were significantly higher than those in another two groups(P<0.05), and were significantly higher in the simple hypertension group than those in the control group(P<0.05). Correlation analysis showed that urine α₁-MG was positively correlated with blood CRP, blood UA, and blood α₁-MG(r=0.858, 0.610, 0.908; P=0.001, 0.001, 0.001). Combined detection of four indicators and three indicators showed significant difference in sensitivity(P<0.05), and - no statistically significant differences in specificity and accuracy(P>0.05). Conclusion Detection of blood CRP, UA, blood α₁-MG and urine α₁-MG in combination can reflect early renal damage degree in elderly patients with essential hypertension, and significantly improve the sensitivity.