Abstract: Objective To study the clinical value of ultrasound-guided femoral nerve-popliteal fossa sciatic nerve block in knee arthroscopic surgery. Methods A total of 50 patients underwent knee arthroscopic surgery were selected as research objects, and were divided into observation group(n=25)and control group(n=25)according to different anesthetic methods. The observation group was given femoral nerve combined with popliteal sciatic nerve anesthesia, and the control group was given lumbar anesthesia alone. The operation time of knee arthroscopic surgeries, changes of heart rate and mean arterial pressure were compared between the two groups before anesthesia and 5, 10, and 15 minutes after injection of anesthetic drugs. The sensory and motor block onset time and duration between the two groups were compared. Results There were no significant differences in heart rate and mean arterial pressure between the two groups before anesthesia and 5, 10 and 15 minutes after injection(P>0.05). The onset time and duration of sensory block and motor block after anesthesia in the observation group were longer than those in the control group(P<0.05). Conclusion Ultrasound-guided femoral nerve-popliteal fossa sciatic nerve block anesthesia is effective in knee arthroscopic surgery, has better postoperative analgesia effect, and can effectively stabilize the hemodynamics of patients.