Abstract: Objective To observe effect of minimally invasive percutaneous locking compression plate internal fixation in treatment of elderly patients with limb fractures. Methods The clinical data of 88 elderly patients with limb fracture was analyzed retrospectively. The patients were divided into two groups according to different operation plans, among whom 42 patients treated with traditional open reduction plate internal fixation were selected as conventional group, and 46 patients treated with minimally invasive percutaneous locking compression plate internal fixation were selected as minimally invasive group. The perioperative basic indicators, incidence of complications, Visual Analogue Scale(VAS)score, fracture healing time and fracture recovery effect were compared between the two groups. Results Compared with the conventional group, operation time and hospitalization time of the minimally invasive group was shorter, perioperative bleeding volume and VAS scores at 3, 7 d after operation were significantly lower(P<0.05); the postoperative complication rate of the minimally invasive group was 4.35%, which was significantly lower than 21.43% of the conventional group(P<0.05). - The results of follow-up at 6 months after surgery showed that patients in two groups had stable plate internal fixation, and no fracture of steel plate and loosening of internal fixation were found. The healing time of fracture in the minimally invasive group was significantly shorter(P<0.05), excellent and good rate of fracture recovery in the minimally invasive group was 97.83%, which was significantly higher than 83.33% in the conventional group(P<0.05). Conclusion Minimally invasive percutaneous locking compression plate internal fixation has a significant effect in the treatment of limb fractures, which can relieve surgical trauma and incidence of complications, and promote bone healing of fractures.