Abstract: Objective To investigate the effect of skin soft tissue expansion and composite skin transplantation on recovery time of wound healing and skin blood supply in burn patients. Methods The clinical data of 79 patients with burn in our hospital was retrospectively analyzed. A total of 39 patients with composite skin transplantation were included in control group, and 40 patients with skin soft tissue expansion were included in research group. The clinical efficacy, wound healing time and recovery time of skin blood supply, and the incidence of postoperative complications were compared between two groups. Results Compared with the control group, the clinical curative efficacy was better, and the wound healing time and recovery time of skin blood supply in the research group was shorter, and the differences were statistically significant(P<0.05). The total incidence of complications in the research group was slightly lower compared with the control group, but showed no significant difference(P>0.05). Conclusion Compared with composite skin transplantation, skin soft tissue expansion in treatment of patients with burn has more significant clinical efficacy, which can shorten the wound healing time and recovery time of skin blood supply, reduce postoperative complications and ensure a higher safety.