Abstract: Objective To explore the effect of enriched autologous concentrated growth factors(CGF)fibrin dressing in treatment of patients with chronic refractory wounds. Methods A total of 70 patients with chronic refractory wounds were randomly divided into control group and experimental group, with 35 cases in each group. The experimental group was treated with enriched autologous CGF fibrin dressing, while the control group was treated with silver ion moist dressing. The wound healing rate, total effective rate and score of Pressure Ulcer Scale for Healing(PUSH)were compared between the two groups after 7, 14 and 28 days of treatment. Results The wound healing rate and total effective rate of the experimental group were significantly higher than those of the control group(P<0.05). The PUSH score of the experimental group was significantly lower than that of the control group after 14 and 28 days of treatment(P<0.05). Conclusion Enriched autologous CGF fibrin dressing is safe and effective in the treatment of patients with chronic refractory wounds, which can improve the therapeutic effect and promote wound healing.