Abstract: Objective To investigate the effect of Shengmai Powder Decoction in the treatment of patients with type 2 diabetes mellitus(T2DM)differentiated as syndrome of Qi and Yin deficiency combined with angina pectoris of coronary heart disease. Methods Totally 80 patients with T2DM differentiated as syndrome of Qi and Yin deficiency combined with angina pectoris of coronary heart disease were randomly divided into two groups, with 40 cases in each group. The control group was treated with western medicine, and the study group was treated with Shengmai Powder Decoction. The levels of serum homocysteine(Hcy)and C reactive protein(CRP), blood glucose indexes ［fasting blood glucose(FPG), glycosylated hemoglobin(HbA1c), fasting insulin(FINS), and insulin resistance index(HOMA-IR)］, frequency of angina pectoris, duration of each attack and electrocardiogram efficacy were compared before and after treatment between the two groups. Results After treatment, the levels of Hcy and CRP were significantly lower than those before treatment in both groups, and the study group was significantly lower than the control group(P<0.05). After treatment, the levels of FPG, HbA1c, FINS and HOMA-IR were significantly lower than those before treatment in both groups, and the study group was significantly lower than the control group(P<0.05). After treatment, the frequency of angina pectoris and duration of each attack in both groups were significantly less or shorter than those before treatment, and the study group was significantly better than the control group(P<0.05). The total effective rate in the study group was 95.00%, which was - significantly higher than 77.50% in the control group(P<0.05). Conclusion Shengmai Powder Decoction is safe and effective in the treatment of patients with T2DM differentiated as syndrome of Qi and Yin deficiency combined with angina pectoris of coronary heart disease, which can relieve the degree of inflammatory reactions, control blood glucose level, alleviate angina symptoms, and improve prognosis.