Abstract: Objective To analyze the risk factors of acute myocardial infarction so as to effectively prevent acute myocardial infarction. Methods Totally 326 patients with coronary heart disease were divided into acute myocardial infarction group(n=156)and chronic stable exertional angina pectoris group(n=170). The general materials such as gender, age, history of hypertension, history of diabetes, history of smoking, history of drinking as well as levels of fasting homocysteine, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, creatinine, urea nitrogen, fasting blood glucose, white blood cell count, neutrophil percentage and high-sensitivity C reactive protein in the morning of the next day after admission were collected in both groups. Results There were significant differences in gender, history of smoking, triglycerides level, total cholesterol level, low-density lipoprotein cholesterol level, homocysteine level, high-sensitivity C reactive protein level, white blood cell count and neutrophil percentage between the two groups(P<0.05). Logistic regression analysis showed that homocysteine, low-density lipoprotein cholesterol, history of smoking, high-sensitivity C reactive protein, white blood cell count and neutrophil percentage were risk factors of acute myocardial infarction(P<0.05). There were significant differences in homocysteine level, high-sensitivity C-reactive protein level, white blood cell count, neutrophil percentage and history of smoking in patients with normal blood lipid level between the two groups(P<0.05). Conclusion Homocysteine, low-density lipoprotein cholesterol, history of smoking, high-sensitivity C reactive protein, white blood cell count and neutrophil percentage are risk factors of acute myocardial infarction. Early intervention for hyperhomocysteinemia can reduce the mortality of patients with acute myocardial infarction.