Abstract: Objective To compare the effect of three antithrombotic treatments following percutaneous coronary intervention(PCI)in patients with atrial fibrillation and coronary heart disease. Methods A total of 90 patients with atrial fibrillation and coronary heart disease treated by PCI were selected as study objects, and randomly divided into group Ⅰ(n=30, treated by warfarin combined with clopidogrel), group Ⅱ(n=30, treated by aspirin combined with clopidogrel), and group Ⅲ(n=30, treated by warfarin, aspirin combined with clopidogrel). The clinical efficacy and the attack of atrial fibrillation were compared. Results The total effective rate in the group Ⅲ was significantly higher than that in the group Ⅰ and the group Ⅱ(P<0.05); after intervention, the frequency of atrial fibrillation attack in the group Ⅲ was significantly lower than that in the group Ⅰ and the group Ⅱ, the duration of atrial fibrillation attack was significantly shorter than that in the group Ⅰ and the group Ⅱ, and the decreased degree of ST segment was significantly lower than that in the group Ⅰ and the group Ⅱ(P<0.05). Conclusion After PCI, patients with atrial fibrillation and coronary heart disease accepting warfarin, aspirin and clopidogrel have better clinical effect, and they have reduced frequency of atrial fibrillation attack, shortened onset duration, and decreased degree of ST segment depression.