Abstract: Objective To investigate the clinical efficacy of Qili Qiangxin Capsule combined with nicorandil in treatment of chronic heart failure. Methods A total of 200 patients with chronic heart failure in our hospital were randomly divided into control group and treatment group, with 100 cases in each group. All patients received normative drug therapy for chronic heart failure, the patients in control group orally took nicorandil tablets, and those in the treatment group orally administrated Qili Qiangxin Capsule based on the control group. Four weeks was a course of treatment, and the treatment was lased for 3 courses. The clinical efficacy and adverse reactions of two groups were observed. Before treatment and at the end of treatment, the changes of laboratory indexes and improvement of cardiac function were compared between two groups. Results At the end of treatment, the total effective rate of the treatment group was significantly higher than that of the control group(95.00% vs. 81.00%, P<0.05); at the end of treatment, left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)in the two groups were lower than those before treatment, and the left ventricular ejection fraction(LVEF)was increased, and there were statistical differences in two groups before and after treatment(P<0.05); at the end of treatment, the LVESD and LVEDD in the treatment group were smaller than those in control group, and the LVEF of the treatment group was higher than that of control group(P<0.05); at the end of - treatment, the high sensitivity C reactive protein(hs-CRP)and cardiac troponin Ⅰ(cTnⅠ), B-type natriuretic peptide(BNP)in two groups were significantly lower than those before treatment(P<0.05); at the end of treatment, the hs-CRP,cTnⅠ and BNP in the treatment group were significantly lower than those in the control group(P<0.05); adverse reactions such as headache, dizziness and insomnia in two groups were found during treatment, but no difference was seen in two groups(P>0.05). Conclusion QiliQiangxin Capsule combined with nicorandil in treatment of chronic heart failure has definite efficacy, which can significantly improve cardiac function, decrease the levels of hs-CRP, cTnⅠ and BNP, and will not increase adverse reactions.