Abstract: Objective To analyze the curative effect of standardized single channel percutaneous nephrolithotomy in the treatment of kidney cast stone. Methods A total of 80 kidney cast stone patients were selected as research objects. According to the method of random number table, the patients were equally divided into control group and observation group. The control group was treated with multi-channel percutaneous nephrolithotomy, while the observation group was treated with standard single channel percutaneous nephrolithotomy. The operation time, intraoperative hemorrhage, hospitalization time, diameter of residual stones in first and second stage surgeries, the clearance rate and complications of the two groups were compared. The blood creatinine levels of the two groups were measured at 1 d before surgery, 1 d and 1 month after surgery. Results The operation time and hospitalization time of the observation group were significantly shorter than that of the control group, and the amount of intraoperative bleeding was significantly less than that of the control group(P<0.05). There were no significant differences in the levels of serum creatinine at 1 d before surgery, 1 d and 1 month after surgery between the observation group and the control group(P>0.05), but the indicators above showed significant differences in the control group(P<0.05). Serum creatinine at 1 d after surgery in the observation group was significantly lower than that in the control group(P<0.05). After the first operation, the diameter of residual stone in the observation group was significantly larger, and the clearance rate was significantly lower than that of the control group(P<0.05); after the second operation, the above indicators showed no significant differences in the observation group and control group(P>0.05). There was no significant difference in the total incidence of complications between the two groups(P>0.05). Conclusion Single channel percutaneous nephrolithotomy in the treatment of kidney cast stone has significant effects, and the patients have less trauma, higher stone clearance rate and faster postoperative recovery.