Abstract: Objective To explore the correlation between lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)in the serum of patients with acute coronary syndrome(ACS)and stability of carotid plaque. Methods A total of 78 patients with ACS were selected as observation group, and were divided into unstable plaque group and stable plaque group according to the results of carotid ultrasound, while the healthy people without plaque were included in control group. The levels of LOX-1 in three groups were detected and comparison between their levels and hypersensitive C reactive protein(hs-CRP)was performed. Results The levels of LOX-1 in the unstable plaque group and stable plaque group were significantly higher than that in the control group, and the level of LOX-1 in the unstable plaque group was significantly higher than that in the stable plaque group(P<0.05). The serum LOX-1 and hs-CRP were negatively correlated with the plaque stability(r=-0.673, -0.554, respectively, P<0.05). Conclusion The serum LOX-1 and hs-CRP levels are closely related to the stability of carotid plaque, which can be used as a serological index to evaluate the stability of ACS plaque.