Abstract: Objective To investigate the effect of Xuefu Zhuyu Decoction combined with drugs for external use in treatment of patients with chloasma complicated with irregular menstruation. Methods A total of 110 patients with chloasma and irregular menstruation were selected and randomly divided into control group(treated with drugs for external use)and study group(treated with Xuefu Zhuyu Decoction and drugs for external use), with 55 cases in each group. The therapeutic effect was compared between the two groups. Results After treatment, the score of irregular menstruation and the area of chloasma in both groups were significantly lower and smaller than those before treatment, and these indexes in study group were significantly lower than the control group(P<0.05). The total effective rate of the study group was 96.36%, which was significantly higher than 81.82% of the control group(P<0.05). After treatment, the levels of vascular endothelial growth factor(VEGF)and epidermal growth factor(EGF)in both groups were significantly higher than those before treatment, and the levels of VEGF and EGF in the study group were significantly higher than those in the control group(P<0.05). Conclusion For patients with chloasma and irregular menstruation, Xuefu Zhuyu Decoction combined with drugs for external use can enhance the curative effect, alleviate the symptoms of irregular menstruation and reduce the area of chloasma, and its mechanism may be related to the regulation of VEGF and EGF levels.