Abstract: Objective To explore the effect of individualized diet nursing intervention on rebleeding of patients with cirrhosis and gastrointestinal bleeding. Methods Totally 90 patients with cirrhosis and gastrointestinal bleeding were selected and randomly divided into observation group and control group, with 45 cases in each group. The control group was given routine nursing intervention, and the observation group was given individualized diet nursing intervention. The hospitalization time, compliance, rebleeding condition, score of quality of life and satisfaction degree, the scores of Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)before and after treatment were compared between two groups. Results The hospitalization time of the observation group was significantly shorter than that of the control group, and the compliance was significantly better than that of the control group(P<0.05). The number of rebleeding and the amount of bleeding in the observation group were significantly less than those in the control group(P<0.05). The HAMD and HAMA scores after nursing in the observation group were significantly lower than those in the control group(P<0.05). The scores of social function, physical function, psychological function and material life status in the observation group were significantly higher than those in the control group(P<0.05). The scores of manipulation, attitude, education and satisfaction degree to therapeutic effect after nursing in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Implementation of individualized diet nursing intervention for patients with cirrhosis and gastrointestinal hemorrhage can shorten the hospitalization time, reduce the rebleeding rate, improve the quality of life and increase the nursing satisfaction degree.