Abstract: Objective To explore the effect of fast track surgery(FTS)concept in the perioperative nursing of patients with radical surgery for colorectal cancer. Methods A total of 94 patients undergoing elective laparoscopic radical resection of colorectal cancer in Department of Colorectal and Anal Surgery were selected and randomly divided into control group and observation group, with 47 cases in each group. The control group was given routine perioperative nursing, while the observation group was given perioperative nursing based on FTS concept. The operation time, operative bleeding volume, time to first anal exhaust, time to first bed-off activity, time to first postoperative food-taking, hospitalization status and incidence of postoperative complications were compared between the two groups. Results The operation was successfully completed in both groups. The time to first anal exhaust, time to first bed-off activity and time to first food-taking after operation in the observation group were significantly shorter than those in the control group(P<0.05). The length of hospital stay and the cost of hospitalization in the observation group were significantly shorter and less than those in the control group(P<0.05). The incidence of complications in the observation group was 8.51%, which was significantly lower than 25.53% in the control group(P<0.05). Conclusion Application of perioperative nursing based on FTS concept can effectively promote the postoperative recovery of patients with radical surgery for colorectal cancer, shorten the length of hospital stay, save the cost of hospitalization, and reduce the incidence of complications.