Abstract: Objective To investigate influencing factors of cancer-related anemia in digestive tract tumor patients. Methods A total of 200 digestive tract tumor patients were selected as the research objects, and the occurrence of cancer-related anemia was analyzed. The influencing factors affecting cancer-related anemia were analyzed by univariate analysis, and risk factors were analyzed by Logistic multivariate regression analysis. Results Out of 200 patients with digestive tract tumors, 124 cases had cancer-related anemia(62.00%), including 32 mild cases, 64 moderate cases, 16 severe cases and 12 extremely severe cases. Univariate analysis showed that there were no significant differences in gender, body mass index, smoking, alcohol drinking and complicating with basic diseases between the two groups(P>0.05); there were significant differences in age, TNM stage, Karnofsky Performance Status(KPS)score, hypoproteinemia and antineoplastic treatment between the two groups(P<0.05). Logistic multivariate regression analysis showed that patients aged over 60 years, at stage of Ⅲ or Ⅳ, with KPS scoring>60, hypoproteinemia and antineoplastic therapy were risk factors for cancer-related anemia. Conclusion The incidence of cancer-related anemia in digestive tract is relatively high, occurring mainly in mild to moderate patients. Over 60 years of age, Ⅲ or Ⅳ staging in TNM stage, KPS scoring over 60, hypoproteinemia and anti-cancer treatment are risk factors for cancer-related anemia.