Abstract: In view of the problem that traditional excitation devices used for magnetic resonance elastography(MRE)cannot achieve a high accuracy and an excellent flexibility at the same time, this paper put forward a new excitation device development for MRE based on the flexible rope drive. Flexible rope was used to transfer the shearing motion and several sets of variable wheels were utilized to flexibly change the path of the rope and high frequency reciprocating motion driver was developed to produce the excitation source, which could obtain MRE excitation devices with high precision and flexibility. The developed excitation device could flexibly adjust the length and path of the rope according to MRE requirements for magnetic shielding and space, and finally can produce excitation signals with frequency ranging from 0 to 100 Hz and a amplitude of 0.5 mm. The device can solve the difficulty that the traditional exciters cannot achieve a high accuracy and a good flexibility simultaneously, and provide equipment support for high-precision MRE.