常规凝血检测与血栓弹力图评价急性脑梗死患者近期预后的价值

Value of routine coagulation test and thrombelastography in evaluating short-term prognosis of patients with acute cerebral infarction

  • 摘要:
      目的  探讨常规凝血检测与血栓弹力图(TEG)对评价急性脑梗死患者近期预后的价值。
      方法  根据患者脑梗死复发情况将86例急性脑梗死患者分为对照组(预后不良)和观察组(预后良好),每组43例。比较2组常规凝血试验指标水平、TEG参数水平。
      结果  2组入院时纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、血小板计数(PLT)水平比较,差异均无统计学意义(P>0.05)。入院时,观察组凝血形成时间、凝血反应时间长于对照组, α角小于对照组,最大振幅低于对照组,差异有统计学意义(P < 0.05)。随访3个月后,观察组最大振幅低于对照组,差异有统计学意义(P < 0.05)。
      结论  TEG检测指标参数与常规凝血检测指标水平具有互补性,且在评价急性脑梗死患者近期预后中具有一定价值。

     

    Abstract:
      Objective  To investigate the value of routine blood coagulation test and thromboelastography (TEG) in evaluating the short-term prognosis of patients with acute cerebral infarction.
      Methods  A total of 86 patients with acute cerebral infarction were divided into control group (poor prognosis) and observation group (good prognosis) according to the recurrence of cerebral infarction, with 43 cases in each group. The indexes of routine coagulation test and TEG parameters were compared in the two groups.
      Results  There were no significant differences in the levels of fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and platelet count (PLT) in the two groups on admission (P>0.05). On admission, the formation time and reaction time of coagulation in the observation group were significantly longer, the α angle was smaller, and the maximum amplitude of clot formation was significantly lower than that in the control group (P < 0.05). After 3 months of follow-up, the maximum amplitude of observation group was significantly lower than that of control group (P < 0.05).
      Conclusion  TEG test parameters are complementary to the level of conventional blood coagulation tests, and it has certain value in the evaluation of short-term prognosis in patients with acute cerebral infarction.

     

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