Abstract: Objective To explore the effect of gastroscope combined with titanium clip in the treatment of patients with ulcerative upper gastrointestinal hemorrhage. Methods Totally 106 patients with ulcerative upper gastrointestinal hemorrhage were divided into control group and study group, with 53 cases in each group. The control group was treated with adrenaline injection under gastroscope, and the study group was treated with gastroscope and titanium clip. The adverse reactions, hemostasis effect, immediate hemostasis rate and rebleeding rate were compared between the two groups. Results The incidence of adverse reactions in the study group was significantly lower than that in the control group(P<0.05). The effective rate of hemostasis in the study group was significantly higher than that in the control group(P<0.05). The immediate hemostasis rate of the study group was significantly higher than that of the control group, and the rebleeding rate was significantly lower than that of the control group(P<0.05). Conclusion Gastroscopy combined with titanium clip can be used as the first choice in the treatment of patients with ulcerative upper gastrointestinal bleeding, which can stop bleeding quickly and effectively, and prevent rebleeding, and it has a low incidence rate of adverse reactions.