Objective  To investigate the effect of propofol combined with oxycodone on inflammatory reactions and stress reactions in patients with acute craniocerebral injury.

  Methods  Totally 95 patients with acute craniocerebral injury were randomly divided into control group (n=47, treated by propofol and remifentanil for anesthesia) and observation group (n=48, treated by propofol and oxycodone hydrochloride for anesthesia). The anesthetic effect, analgesic effect, oxidative stress reactions of brain tissues and adverse reactions were compared between the two groups.

  Results  The postoperative recovery time of anesthesia, extubation time, eye-opening time, mean arterial pressure (MAP) and heart rate (HR) of the observation group were significantly shorter or lower than those of the control group (P < 0.05). The VAS scores of the observation group at 1 hour, 6, 12 and 24 hours after operation were significantly lower than those of the control group (P < 0.05). The levels of myelin basic protein (MBP), neuron specific enolase (NSE), S-100B protein and D-dimer (D-D) in the observation group were significantly lower than those in the control group during operation and 24 hours after operation (P < 0.05). The incidence of adverse reactions in the observation group was 10.42%, which was significantly lower than 27.66% in the control group (P < 0.05).

  Conclusion  Propofol combined with oxycodone can reduce the oxidative stress degree of brain tissue in patients with acute craniocerebral injury, improve the effects of anesthesia and analgesia, and cause less adverse reactions.