Abstract: Objective To explore the application effect of meticulous nutrition management in chronic kidney disease patients with malnutrition. Methods Totally 43 patients with chronic renal disease and malnutrition from June to December 2018 were selected as control group, and routine diet management was adopted. Totally 45 patients with chronic renal disease and malnutrition from January to June 2019 were selected as observation group, and meticulous nutrition management was adopted. The dietary knowledge-attitude-behavior condition and nutritional status were compared between the two groups. Results The dietary cognition-attitude-behavior condition of the observation group was significantly better than that of the control group(P<0.05). The contents of serum albumin and total protein in the observation group were significantly higher than those in the control group, and improved Subjective Global Assessment(SGA)score was significantly lower than that in the control group(P<0.05). Conclusion Meticulous nutrition management is beneficial to improve dietary knowledge-attitude-behavior condition and nutritional status in the chronic kidney disease patients with malnutrition.