Abstract: Objective To investigate the effect of shared decision-making intervention on level of hope and compliance to intervention in patients with in vitro fertilization-embryo transfer(IVF-ET). Methods A total of 102 patients with IVF-ET were selected and randomly divided into observation group and control group, with 51 cases in each group. Control group was given routine nursing intervention, and observation group was given shared decision-making intervention on the basis of control group. The disease-related knowledge mastery, psychological status and hope level were compared between the two groups before and after intervention, and the compliance to intervention and pregnancy outcomes were recorded. Results After intervention, the scores of mastery degrees of disease-related knowledge and hope level in both groups were significantly higher than those before intervention, and the scores of indexes above in the observation group were significantly higher than those in the control group(P<0.05). After intervention, the scores of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)in both groups were significantly lower than those before intervention, and the scores of indexes above in the observation group were significantly lower than those in the control group(P<0.05). After intervention, the total compliance rate of the observation group was significantly higher than that of the control group, and the number of obtained ovum was significantly more than that of the control group(P<0.05). There were no significant differences in number of transferred embryos, abortion rates and clinical pregnancy rate between the two groups(P>0.05). Conclusion Shared - decision-making intervention can significantly improve the psychological status of patients with IVF-ET, alleviate the negative emotions, enhance the hope level and compliance to intervention, and improve the pregnancy rate.