Abstract: Objective To investigate the effect of proximal femoral interlocking intramedullary nail antirotation(PFNA)in the treatment of senile patients with intertrochanteric comminuted fracture of femur. Methods Ninety elderly patients with comminuted intertrochanteric fracture of femur were selected and divided into two groups according to surgical methods. The control group(n=45)was treated with dynamic hip screw internal fixation, and the study group was treated with PFNA(n=45). The short-term and long-term recovery of hip function, the time of weight-bearing after operation, the amount of bleeding during operation and the incidence of complications were compared between the two groups. Results The excellent and good rates of hip function recovery in the study group was 71.11% and 97.78% at 3 months and 1 year after operation, which were significantly higher than 48.89% and 82.22% in the control group(P < 0.05). The weight-bearing time in the study group was significantly shorter than that in the control group, and the amount of bleeding in the operation was significantly less than that in the control group(P < 0.05). The incidence rate of perioperative complications in the study group was 4.44%, which was significantly lower than 20.00% in the control group(P < 0.05). Conclusion For elderly patients with intertrochanteric comminuted fracture of femur, PFNA can reduce the complications after operation, precipitate the early bed-off activity and promote the long-term recovery of hip function with minimally invasive.