Abstract: Objective To compare the effect of internal fixation with proximal femoral nail antirotation(PFNA)and internal fixation with dynamic hip screw(DHS)in treatment of patients with intertrochanteric fracture of femur. Methods A total of 100 patients with intertrochanteric fracture of femur were selected and divided into control group and observation group according to the order of hospital admission. The control group and was treated by DHS with internal fixation, and the observation group was treated by PFNA with internal fixation. Treatment effect, degree of pain, joint function, complications and quality of life were compared between the two groups. Results The operation time, healing time and hospitalization time in the observation group were significantly shorter than those in the control group, and the amount of bleeding was significantly less than that in the control group(P < 0.05). The VAS score of the observation group was significantly lower than that of the control group, and the Harris score was significantly higher than that of the control group(P < 0.05). The incidence rate of complications in the observation group was significantly lower than that in the control group(P < 0.05). There was a significant difference in quality of life between the two groups(P < 0.05). Conclusion Internal fixation with PFNA is effective and safe in the treatment of patients with intertrochanteric fracture of femur, which can promote the recovery of limb joint function and improve the quality of life.