Abstract: Objective To explore the clinical effect of feed-forward control on the nursing safety management in patients with percutaneous coronary intervention(PCI). Methods A total of 100 patients with PCI were randomly divided into control group and experimental group, with 50 cases in each group. The patients in the control group received routine nursing safety management, while the patients in the experimental group received feed-forward control on the basis of the control group. The nursing quality and cardiovascular events were compared between the two groups. Results After applying feed-forward control in the nursing safety management of PCI patients, the risk awareness and anti-risk ability of nurses in the ward significantly improved, the nursing risk after PCI significantly reduced, and the patients' satisfaction degrees significantly improved. Compared with the control group, the restenosis rate, arrhythmia rate and readmission rate of the experimental group were significantly lower(P < 0.05). Conclusion Feed-forward control can enhance the quality of nursing, improve the quality of life of PCI patients and reduce the incidence of malignant diseases.