Abstract: Objective To explore curative effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke(IS)and its influence on cerebral blood flow(CBF). Methods A total of 533 IS patients who were admitted to the hospital were enrolled as study objects. According to different treatment plans, they were divided into three groups. A total of 217 patients treated with aspirin were included in aspirin group, 184 patients treated with Naoxuekang Capsules were included in Naoxuekang group, and 132 patients treated with aspirin and Naoxuekang Capsules were included in combination group. The clinical curative effect, score of National Institutes of Health Stroke Scale(NIHSS), platelet aggregation rate, cerebral blood flow velocity and cerebral blood flow volume were compared among the three groups. Results The total response rate of treatment in combination group was 91.67%, which was significantly higher than 82.95% in aspirin group and 80.98% in Naoxuekang group(P < 0.05). After 1-, 2- and 3- month treatment, NIHSS score and platelet aggregation rate in combination group were lower than those in aspirin group and Naoxuekang group(P < 0.05). The cerebral blood flow velocity and cerebral blood flow volume in combination group were higher than those in aspirin group and Naoxuekang group(P < 0.05). There were no significant differences in total response rate of treatment, NIHSS score, platelet aggregation rate, cerebral blood flow velocity or - cerebral blood flow volume between aspirin group and Naoxuekang group(P > 0.05). Conclusion The antithrombotic effect of Naoxuekang Capsule is similar to that of aspirin. The combined application of Naoxuekang Capsule and aspirin in IS patients can improve nerve function, increase cerebral blood flow volume, and improve curative effect.