Abstract: Objective To investigate the effect of modified Xinglou Chengqi Decoction on oxidative stress reactions in patients with acute cerebral infarction differentiated as phlegm-heat and sthenic-fu syndrome after intravenous thrombolysis. Methods A total of 80 patients with acute cerebral infarction differentiated as phlegm-heat and sthenic-fu syndrome who admitted in our hospital were selected, and were divided into control group(n=40)and research group(n=40)according to random number table method. Control group was given routine western medicine after intravenous thrombolysis, and research group was treated with modified Xinglou Chengqi Decoction on thrombolysis day based on the control group. The clinical efficacy of two groups was analyzed. The oxidative stress reactions and inflammatory factors before and after treatment were observed. Results The total effective rate of research group was significantly higher than that of control group(P < 0.05). After treatment, the levels of malondialdehyde(MDA), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α)in research group were lower, and the superoxide dismutase(SOD)was higher than that of control group(P < 0.05). Conclusion Modified Xinglou Chengqi Decoction in treatment of phlegm-heat and sthenia-fu syndrome of acute cerebral infarction after intravenous thrombolysis is effective, it can improve oxidative stress indexes and levels of inflammatory factors, and promote nerve restoration.