Abstract: Objective To explore the clinical value of cardiac color Doppler ultrasound in diagnosis of children with congenital heart disease. Methods Clinical materials of 150 children with suspected congenital heart disease were analyzed retrospectively, and they were confirmed by surgery and pathology examination, and all of them were conducted with preoperative cardiac color Doppler ultrasound diagnosis. The accuracy, specificity and sensitivity of cardiac color Doppler ultrasound in the diagnosis of congenital heart disease were analyzed. Results There were no significant differences in the accuracy, specificity and sensitivity between surgical pathology and cardiac color Doppler(P > 0.05). The accuracy of the qualitative diagnosis of cardiac color Doppler ultrasound for congenital heart disease was 97.58%. Conclusion Cardiac color Doppler ultrasound has a significant value in the diagnosis of children with congenital heart disease, which has higher accuracy, specificity and sensitivity.