血清热休克蛋白90早期诊断肝细胞癌的价值

Value of serum heat shock protein 90 in early diagnosis of hepatocellular carcinoma

摘要:
目的探讨血清热休克蛋白90(HSP90)在肝细胞癌(HCC)早期诊断中的价值。
方法检测240例HCC患者血清HSP90及甲胎蛋白(AFP)水平。采用受试者工作特征(ROC)曲线评估HSP90和AFP对HCC的敏感性。
结果 HSP90诊断HCC的敏感性和特异性分别为89.38%和42.86%, 而血清AFP诊断HCC的敏感性和特异性分别为71.68%和64.28%, 差异有统计学意义(P < 0.05)。
结论 HSP90是辅助AFP提高HCC诊断准确率的重要血清标志物，在临床应用中具有一定的价值。

Abstract:
Objective To investigate the value of serum heat shock protein 90 (HSP90) in the early diagnosis of hepatocellular carcinoma (HCC).
Methods Levels of serum HSP90 and alpha-fetoprotein (AFP) were detected in 240 patients with HCC. Receiver operating characteristic (ROC) curve was used to evaluate the sensitivity of HSP90 and AFP in diagnosis of HCC.
Results The sensitivity and specificity of HSP90 in the diagnosis of HCC were 89.38% and 42.86%, respectively, while the sensitivity and specificity of serum AFP in the diagnosis of HCC were 71.68% and 64.28%, respectively, and there were significant differences between two indexes (P < 0.05).
Conclusion HSP90 is an important serum marker to assist AFP in improving the diagnostic accuracy of HCC, and has a certain value in clinical application.