Value of critical illness score combined with serum D-dimer and procalcitonin in the evaluation of infection condition in children
-
摘要: 目的 探讨危重病例评分联合血清D-二聚体(D-D)、降钙素原(PCT)对儿童感染病情的评估价值。 方法 将102例感染儿童依据感染类型分为病毒感染组29例与细菌感染组73例,根据感染程度分为普通感染组65例与重度感染组37例。选取同期健康儿童96例作为对照组。比较各组儿童危重病例评分、血清D-D及PCT的含量,分析各个指标评估儿童感染病情的价值。 结果 细菌感染组、对照组、病毒感染组的危重病例评分、血清D-D含量、血清PCT含量两两比较,差异均有统计学意义(P<0.05)。重度感染组、普通感染组、对照组的危重病例评分、血清D-D含量、血清PCT含量两两比较,差异均有统计学意义(P<0.05)。危重病例评分、血清D-D、血清PCT联用对儿童感染病情评估的敏感性为90.2%, 特异性为95.8%, 阳性预测值为95.8%, 阴性预测值为90.2%。 结论 危重病例评分联合血清D-D、PCT在儿童感染病情早期评估中具有重要的临床意义。Abstract: Objective To explore the value of critical illness score combined with serum D-dimer(D-D)and procalcitonin(PCT)in the evaluation of infection condition in children. Methods Totally 102 infected children were divided into virus infection group(n=29)and bacteria infection group(n=73)according to infection type, and they were also divided into common infection group(n=65)and severe infection group(n=37)according to the degree of infection. At the same time, 96 healthy children were selected as control group. The critical illness score, the contents of serum D-D and PCT were compared between each group, and the value of each index in evaluation of the infection condition in children was analyzed. Results There were significant differences in critical illness score, serum D-D content and serum PCT content between two groups in bacterial infection group, control group and virus infection group(P<0.05). There were significant differences in critical illness score, serum D-D content and serum PCT content between two groups in severe infection group, common infection group and control group(P<0.05). In the evaluation of infection condition by combination of critical illness score, serum D-D and PCT, the sensitivity, specificity, positive predictive value and negative predictive value were 90.2%, 95.8%, 95.8% and 90.2% respectively. Conclusion Critical illness score combined with serum D-D and PCT has an important clinical significance in early evaluation of infection condition in children.
-
Keywords:
- critical illness score /
- D-dimer /
- procalcitonin /
- infection condition /
- evaluation value
-
-
文艺, 董玉斌, 张君, 等. 小儿危重病例评分联合D-二聚体及降钙素原检测用于儿童感染病情的早期评判[J]. 临床心身疾病杂志, 2018, 24(2): 38-41 , 45.
王志华, 齐欣, 王改, 等. 小儿脓毒症血清sE-选择素、D-二聚体检测的临床意义[J]. 医学综述, 2016, 22(6): 1207-1208 , 1211.
王佳颖, 胡晓渤, 刘湘, 等. D-二聚体阳性患者在临床科室的分布及其检测临床意义[J]. 国际检验医学杂志, 2015, 36(10): 1421-1422. 冯金, 罗文婷, 陈贤华. D-二聚体在临床中的应用[J]. 医学信息, 2014, 27(8): 535-536. Willson D F, Webster A, Heidemann S, et al. Diagnosis and Treatment of Ventilator-Associated Infection: Review of the Critical Illness Stress-Induced Immune Suppression(CRISIS)Prevention Trial Data[J]. Pediatric Critical Care Medicine, 2016, 17(4): 287-293.
隆维东, 黄冬悦, 刘锋, 等. 小儿危重病例评分联合D-二聚体和降钙素原检测对儿童感染病情的早期评判价值[J]. 河北医药, 2017, 39(5): 701-703. Hu R M, Gong Y S, Wang Y Z. Relationship of serum procalcitonin levels to severity and prognosis in pediatric bacterial meningitis[J]. Clin Pediatr(Phila), 2015, 54(12): 1141-1144.
Umran R M, Radhi N H. Diagnostic value of serum procalcitonin level in differentiating bacterial from nonbacterial meningitis in children[J]. Iran J Pediatr, 2014, 24(6): 739-744.
穆原, 沈京培, 管贤伟, 等. 小儿危重病例评分联合 D-二聚体及降钙素原检测用于儿童感染病情的早期评判[J]. 中华实用儿科临床杂志, 2016, 31(6): 425-428. 曹校校, 李强, 陈荣. 降钙素原与C-反应蛋白联合检测在成人细菌性肺炎中的临床评价[J]. 中华医院感染学杂志, 2014, 24(19): 4933-4935. 张娙, 董静莲, 王书亮. 降钙素原与D-二聚体在评估急诊脓毒症患者病情及预后的研究[J]. 中华医院感染学杂志, 2015, 25(1): 11-13. Nazerian P, Morello F, Vanni S, et al. Combined use of aortic dissection detection risk score and D-dimer in the diagnostic workup of suspected acute aortic dissection[J]. Int J Cardiol, 2014, 175(1): 78-82.
Mihajlovic D, Lendak D, Mitic G, et al. Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in Sepsis[J]. Turk J Med Sci, 2015, 45(1): 93-98.
翁艳. 小儿危重病例评分联合血清D-二聚体及降钙素原水平对儿童感染病情的早期评估[J]. 中国妇幼保健, 2017, 32(3): 528-529. 张娙, 董静莲, 王书亮. 降钙素原与D-二聚体在评估急诊脓毒症患者病情及预后的研究[J]. 中华医院感染学杂志, 2015, 25(1): 11-13. 曾庆娣, 林爱翠. 肺炎支原体抗体C-反应蛋白及血清降钙素原检测在儿童呼吸道医院感染诊断中的应用评价[J]. 河北医学, 2016, 22(4): 563-566. 杨欣悦, 钱传云, 樊楚明. 高敏C-反应蛋白与降钙素原对感染性疾病预后评估研究[J]. 中华医院感染学杂志, 2014, 24(1): 22-24. 岑院华. 血清C反应蛋白、降钙素原检测在儿童感染性疾病诊断中的应用评价[J]. 中国卫生检验杂志, 2015, 25(7): 996-998. -
期刊类型引用(3)
1. 张盼，王禺，李秀娥，王彩娥，刘媛. 纤维蛋白原、D-二聚体及血栓四项在中老年肾病综合征患者检测中的应用价值. 中国临床实用医学. 2024(05): 29-34 . 
百度学术
2. 顾志坚. 血清降钙素原在重症感染患者临床治疗中的应用效果探讨. 系统医学. 2021(14): 35-38 . 百度学术
3. 乐大峰，杨君华，李声凤. 肾病综合征合并感染患者血清D-二聚体、IL-6、TNF-α水平变化及临床意义. 热带医学杂志. 2021(09): 1205-1208 . 百度学术
其他类型引用(0)
计量
- 文章访问数: 306
- HTML全文浏览量: 83
- PDF下载量: 9
- 被引次数: 3
下载:
苏公网安备 32100302010246号