Abstract: Objective To compare the effect of local heparin anticoagulation and local citrate anticoagulation in patients with sepsis caused by critical burn by treatment of continuous blood purification(CBP). Methods A total of 90 patients with sepsis caused by critical burn by treatment of CBP were selected and divided into two groups, with 45 cases in each group. Local heparin anticoagulation was used in the control group, while local citrate anticoagulation was used in the study group. The indexes of coagulation, inflammatory factors and adverse reactions were compared before and after treatment between two groups. Results After treatment, prothrombin time and activated partial thromboplastin time in the study group were significantly shorter than those in the control group(P<0.05), and the levels of serum procalcitonin and C reactive protein were significantly lower than those in the control group(P<0.05). The incidence rate of adverse reactions in the study group was significantly lower than that in the control group(P<0.05). Conclusion For patients with sepsis caused by critical burn by treatment of CBP, the local citrate anticoagulation has better effect and higher safety, which can reduce the influence on the systemic coagulation state of patients.