Abstract: Objective To investigate the differences in the establishment of healthy lifestyle patterns and metabolic indicators in overweight patients newly diagnosed as type 2 diabetes by flash glucose monitoring versus traditional fingertip blood glucose monitoring. Methods A total of 102 overweight patients newly diagnosed as type 2 diabetes were randomly divided into study group and control group. The study group treated with metformin and flash glucose monitoring system for blood glucose management and life style intervention. The control group was treated with metformin and periodically detection of blood glucose level by fingertip blood glucose monitoring. The blood glucose at different time points were recorded. The metabolic indicators such as body weight, waist circumference, blood glucose, blood lipids and islet function before and after intervention were compared and the changes in self-administration behavior scale(SDSCA)scores of these patients were observed. Results After 14 days of intervention, the SDSCA scores of both two groups were higher than baseline, and the difference was statistically significant(P<0.05). The variations of body weight(△BW), body mass index(△BMI), waist circumference(△WC), triglyceride(△TG), fasting plasma glucose(△FPG), insulin(△Ins), uric acid(△UA), △SDSCA before and after intervention of two groups were statistically significant(P<0.05), but the variations of △TC(total cholesterol), low density lipoprotein cholesterol(△LDL-C), high density lipoprotein cholesterol(△HDL-C)- showed no statistically significant(P>0.05). During 14-day intervention period, the difference of standard deviation of blood glucose(SDBG)and mean amplitude of glycemic excursions(MAGE)were lower in the study group than in the controgroup(P< 0.05). Conclusion The flash glucose monitoring system promotes healthy life style compared with traditional fingertip blood glucose monitoring. It is beneficial for overweight patients newly diagnosed as type 2 diabetes to control weight, blood sugar and blood lipids, relieve insulin resistance and improve islet function.