Abstract: Objective To explore the application of "one-stop" dual interventional technique in treatment of pernicious placenta previa. Methods The clinical data of 46 patients with pernicious placenta previa from August 2014 to July 2018 in Subei People's Hospital was analyzed retrospectively. Among them, 20 pregnant women underwent cesarean section of lower uterine segment were selected as control group, and 26 pregnant women underwent bilateral internal iliac artery balloon implantation combined with cesarean section of lower uterine segment and selective artery embolization were selected as experimental group. The surgical indexes and postoperative complications were compared between the two groups. Results The bleeding volume, blood transfusion volume and hysterectomy rate in the experimental group were significantly higher than those in the control group(P<0.05). There were no significant differences in the amount of bleeding, hospitalization time, postoperative hospitalization time and neonatal asphyxia rate between the two groups(P>0.05). The incidence rate of lumbago pain, abdominal pain and buttock pain as well as duration of lumbago and abdominal pain in experimental group were significantly higher or longer than those in control group(P<0.05). Conclusion The "one-stop" dual interventional technique, with higher safty can significantly reduce the blood loss and hysterectomy rate in patients with pernicious placenta previa.