2型糖尿病患者健康体检中幽门螺杆菌检查的必要性分析

崔乐乐; 卢金婧; 张耐思; 裴冬梅

doi:10.7619/jcmp.201924017

2型糖尿病患者健康体检中幽门螺杆菌检查的必要性分析

Analysis in necessity of Helicobacter pylori infection screening in healthy physical examinations of patients with type 2 diabetes mellitus

摘要

摘要:
目的探讨2型糖尿病患者健康体检中幽门螺杆菌(Hp)检查的必要性。
方法采用¹⁴C尿素酶呼气实验方法检测1 897例2型糖尿病患者、750例空腹血糖受损患者、800例非糖尿病对照组体检者的Hp感染情况并进行比较, 并将1 004例糖尿病患者根据Hp感染情况分为感染亚组及非感染亚组，比较2组患者的血糖、血脂差异。
结果 2型糖尿病患者的Hp感染阳性率为47.8%, 空腹血糖受损患者的Hp感染阳性率为41.6%, 均高于非糖尿病对照组体检者的34.8%, 差异有统计学意义(P < 0.01); 2型糖尿病患者中Hp感染亚组及非感染亚组间的空腹血糖、血清总胆固醇、低密度脂蛋白胆固醇、甘油三脂、高密度脂蛋白胆固醇比较，差异有统计学意义(P < 0.05)。
结论 2型糖尿病患者更容易感染Hp, Hp感染对2型糖尿病的血糖、血脂代谢可能有一定影响，本研究提示对2型糖尿病患者进行Hp检测是有一定意义的。

Abstract:
Objective To investigate Helicobacter pylori (Hp) infection screening in healthy physical examinations of patients with type 2 diabetes mellitus.
Methods The Hp infection conditions of 1 897 cases with type 2 diabetes, 750 cases with impaired fasting glucose and 800 healthy controls were detected and compared by exhale urease breath test method. Out of these patients, 1 004 cases with type 2 diabetes were divided into Hp infection sub-group and Hp non-infection sub-group. Differences of blood glucose and blood lipid were compared between the two groups.
Results Hp infection positive rate in type 2 diabetes mellitus patients and those with impaired fasting glucose were 47.8%, 41.6%, respectively, which were significantly higher than 34.8% in the control group. There were significant differences in fasting blood glucose, serum total cholesterol, low-density lipoprotein cholesterol, triglyceride and high-density lipoprotein cholesterol between HP infected and non-infected subgroups(P < 0.05).
Conclusion Type 2 diabetes mellitus patients are more likely to be infected with by Hp, and it may impact on glucose and lipid metabolism in patients with type 2 diabetes. Therefore, it is of great significance to detect Hp in type 2 diabetic patients.

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