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慢性阻塞性肺疾病患者肠道菌群特点及其与炎症指标、肺功能状况的相关性

Characteristics of intestinal microflora in patients with chronic obstructive pulmonary disease and its correlation with inflammatory indexes and pulmonary function

    摘要
  • 摘要:
      目的  探讨慢性阻塞性肺疾病(COPD)患者肠道菌群特点及其与炎症指标、肺功能状况的相关性。
      方法  选取104例COPD患者为观察组，选取80例健康者为对照组。比较2组患者的肠道菌群数; 比较2组血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平; 比较2组第1秒用力呼气容积占预计值百分比(FEV1%)及第1秒用力呼气容积占用力肺活量比(FEV1/FVC)。分析肠道菌群特点与炎症指标及肺功能状况的相关性。
      结果  与对照组比较，观察组需氧菌种类无明显变化，厌氧菌中梭状杆菌数显著多于对照组(P < 0.05)。观察组真菌株数多于对照组。观察组定植在肠道内的双歧杆菌属、乳酸杆菌属数量(粪便)低于对照组，差异有统计学意义(P < 0.05)。观察组血清hs-CRP、TNF-α、IL-6水平高于对照组，差异有统计学意义(P < 0.05)。观察组FEV1/FVC及FEV1%均低于对照组，差异有统计学意义(P < 0.05)。Pearson相关分析结果显示，观察组双歧杆菌属与FEV1/FVC、FEV1%、hs-CRP、TNF-α、IL-6呈显著负相关(r=-0.524、-0.498、-0.477、-0.512、-0.508, P均 < 0.05), 乳酸杆菌属与FEV1/FVC、FEV1%、hs-CRP、TNF-α、IL-6也呈显著负相关(r=-0.576、-0.466、-0.442、-0.523、-0.439, P均 < 0.05)。
      结论  COPD患者肠道菌群数与炎性指标及肺功能呈显著负相关。

     

    Abstract:
      Objective  To explore the characteristics of intestinal microflora in patients with chronic obstructive pulmonary disease (COPD) and its correlation with inflammatory indexes and pulmonary function.
      Methods  A total of 104 patients with COPD were selected as observation group, and 80 healthy people were selected as control group. The intestinal microflora was compared between two groups. The serum levels of high sensitive C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) andinterleukin-6 (IL-6) were compared between two groups. The forced expiratory volume in the first second as a percentage of the expected value (FEV1%) and the ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) were compared between two groups. Correlation between the characteristics of intestinal microflora and inflammatory indexes as well as pulmonary function were analyzed.
      Results  Compared with the control group, there was no significant change in the type of aerobic bacteria in the observation group, and the number of clostridium in the anaerobic bacteria was significantly higher than that in the control group (P < 0.05). The number of fungi in the observation group was more than that in the control group. The numbers of bifidobacteria and lactobacilli (feces) in the observation group were significantly lower than those in the control group (P < 0.05). The levels of serum hs-CRP, TNF-α and IL-6 in the observation group were significantly higher than those in the control group (P < 0.05). FEV1/FVC and FEV1% in the observation group were significantly lower than those in the control group (P < 0.05). Pearson correlation analysis showed that there were significant negative correlations between bifidobacteria and FEV1/FVC, FEV1%, hs-CRP, TNF-α, IL-6 (r=-0.524、-0.498、-0.477、-0.512、-0.508, P < 0.05), and lactobacilli was also negatively correlated with FEV1/FVC, FEV1%, hs-CRP, TNF-α, IL-6 (r=-0.576、-0.466、-0.442、-0.523、-0.439, P < 0.05).
      Conclusion  There is a significant negative correlation between intestinal microflora and inflammatory indexes and pulmonary function in COPD patients.

     

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