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哮喘儿童呼出气一氧化氮检测和肺泡一氧化氮质量浓度检测的临床价值

Clinical value of fractional exhaled nitric oxidemonitoring and detection of alveolar nitric oxide concentration in children with asthma

    摘要
  • 摘要:
      目的  探讨哮喘儿童呼出气一氧化氮(FeNO)检测和肺泡一氧化氮质量浓度(CANO)检测的临床价值。
      方法  回顾性分析79例FeNO水平哮喘患儿的临床资料, 根据儿童哮喘控制测试(C-ACT)评分将患儿分为轻度哮喘组7例、中度哮喘组46例、重度哮喘组26例，另选择同期健康体检儿童66名设为对照组，分析FeNO检测和CANO检测在哮喘儿童诊治中的应用效果。
      结果  重度哮喘组FeNO、CANO水平高于中度哮喘组、轻度哮喘组、对照组，差异均有统计学意义(P < 0.05); 重度哮喘组第1秒用力呼气容积占预计值的百分比(FEV1%)、用力呼气峰流速占预计值的百分比(PEF%)低于中度哮喘组、轻度哮喘组、对照组，差异均有统计学意义(P < 0.05); Pearson相关性分析发现, FEV1%与FeNO呈负相关性(r=-0.239, P < 0.05); CANO与FeNO呈正相关性(r=0.511，P < 0.01)。
      结论  FeNO、CANO与肺功能具有相关性，可作为评估FeNO水平哮喘患儿病情的指标，指导临床后续治疗。

     

    Abstract:
      Objective  To investigate the clinical value of fractional exhaled nitric oxide (FeNO) monitoring and detection of alveolar nitric oxide concentration (CANO) in children with asthma.
      Methods  The clinical data of 79 asthma children with FeNO was retrospectively analyzed. According to the score of childhood asthma control test (C-ACT), all selected cases were divided into mild asthma group (7 cases), moderate asthma group (46 cases) and severe asthma group (26 cases). And 66 healthy children with physical examination were selected as control group. The effects of FeNO monitoring and CANO detection in diagnosis and treatment of children with asthma were analyzed.
      Results  The levels of FeNO and CANO in severe asthma group were higher than those in moderate asthma group, mild asthma group and control group (P < 0.05); The forced expiratory volume in one second (FEV1%) and peak expiratory flow (PEF%) in severe asthma group were lower than those in moderate asthma group, mild asthma group and control group (P < 0.05). Pearson correlation analysis showed that FENO was negatively correlated with FEV1%(r=-0.239, P < 0.05), and positively correlated with CANO(r=0.511, P < 0.01).
      Conclusion  FENO and CANO are correlated with pulmonary function, which can be indicators for assessing the condition of children with FENO asthma and guiding the following clinical treatment.

     

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