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外周血CD4+T细胞亚群中趋化性细胞因子受体5的表达水平与颈动脉狭窄的相关性研究

Correlation between expression levels of chemokine cytokine receptor 5 in CD4+ T cell subsets in peripheral blood and carotid stenosis

    摘要
  • 摘要:
      目的  探讨CD4+T细胞亚群中趋化性细胞因子受体5(CCR5)的表达水平与颈动脉狭窄程度是否存在相关性。
      方法  选取84例颈动脉狭窄患者设为颈动脉狭窄组, 依照颈动脉狭窄率分为轻度狭窄组30例、中度狭窄组28例及重度狭窄组26例，另选取45名颈动脉正常者设为对照组。采用流式细胞术检测受试者外周血CD4+T细胞CCR5的表达水平。
      结果  各颈动脉狭窄亚组与对照组的年龄、性别、高血压、血脂异常、糖尿病、吸烟等一般资料相比，差异无统计学意义(P>0.05); 颈动脉狭窄组的CD4+CCR5表达水平高于对照组, 各颈动脉狭窄亚组的CD4+CCR5的表达水平也高于对照组，差异有统计学意义(P < 0.05); 重度狭窄组的CD4+CCR5表达水平高于轻度狭窄组(P < 0.05); 各组间CD4+亚群在T细胞中的占比差异无统计学意义(P>0.05)。
      结论  外周血CD4+T细胞CCR5表达水平的升高与颈动脉狭窄关系密切, 对判断颈动脉狭窄程度可能有一定提示作用。

     

    Abstract:
      Objective  To investigate whether there was a correlation between expression level of chemokine cytokine receptor 5 (CCR5) in CD4+ T cell subsets and degree of carotid stenosis.
      Methods  Eighty-four patients with carotid stenosis were selected as the carotid stenosis group. According to the carotid stenosis rate, they were divided into mild stenosis group with 30 cases, moderate stenosis group with 28 cases and severe stenosis group with 26 cases. Another 45 subjects with normal carotid artery were selected as the control group. Flow cytometry was used to detect the expression level of CCR5 in CD4+ T cells in peripheral blood of subjects.
      Results  There were no significant differences in terms of age, gender, hypertension, dyslipidemia, diabetes, smoking and other general information in all groups (P>0.05); the expression levels of CD4+CCR5 in patients with carotid stenosis were higher than the controls (P < 0.05); its level in severe stenosis group was higher than mild stenosis group(P < 0.), but no significant differences were observed in CD4+CCR5 level(P < 0.). There were no statistically significant between-group difference in the proportions of CD4+ subgroups in T cells (P>0.05).
      Conclusion  The increase of CCR5expression in peripheral blood CD4+ T cells is closely related to carotid stenosis, which may have a certain role in judging the degree of carotid stenosis.

     

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