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丝裂原活化蛋白激酶4和波形蛋白联合检测对子宫内膜癌的早期诊断价值

Value of detection of mitogen-activated protein kinase 4 combined with vimentin in early diagnosis of endometrial cancer

    摘要
  • 摘要:
      目的  研究丝裂原活化蛋白激酶4(MAP2K4)和波形蛋白联合检测运用于子宫内膜癌中的诊断价值。
      方法  选择103例子宫内膜癌患者为研究对象, 检测MAP2K4、波形蛋白，探讨联合检测的诊断价值。
      结果  MAP2K4检测阳性率为37.86%(39/103), 低于波形蛋白的阳性率65.05%(67/103), 且阳性细胞所占比例积分及着色强度评分较波形蛋白更低，差异有统计学意义(P < 0.05); MAP2K4的阳性表达与患者的FIGO分期、淋巴转移有显著相关性，而波形蛋白的阳性表达与患者的FIGO分期、组织学分型、浸润深度及淋巴转移有显著相关性(P < 0.05)。MAP2K4和波形蛋白联合检测的灵敏度、特异性显著高于单一检测(P < 0.05)。
      结论  MAP2K4和波形蛋白联合检测运用于子宫内膜癌早期诊断中效果明显，为预后提供参考依据。

     

    Abstract:
      Objective  To study the diagnostic value of combined detection of mitogen-activated protein kinase 4(MAP2K4) and vimentin in diagnosis of endometrial cancer.
      Methods  A total of 103 patients with endometrial cancer were selected as study subjects. MAP2K4 and vimentin were detected respectively, and diagnostic value of combined detection was explored.
      Results  The endometrial cancer-positive rate detected by MAP2K4 was significantly lower than that of vimentin37.86% (39/103) vs. 65.05%(67/103), the proportion score and staining intensity score of positive cells were also significantly lower than those of vimentin(P < 0.05). The positive expression of MAP2K4 was significantly correlated with FIGO staging and lymph node metastasis, while the positive expression of vimentin was significantly correlated with FIGO staging, histological types, invasion depth and lymph node metastasis (P < 0.05). The sensitivity and specificity of combined detection of MAP2K4 and vimentin were significantly higher than that of single detection(P < 0.05).
      Conclusion  The combined detection of MAP2K4 and vimentin has obvious effect in the diagnosis of endometrial cancer, which can provide reference for prognosis.

     

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