Objective  To explore intestinal barrier function of non-acute ischemic stroke patients and its risk factors.

  Methods  A total of 67 patients with non-acute ischemic stroke in our hospital were selected as experimental group, and 70 patients with non-ischemic stroke during the same period were as control group. The indicators of intestinal barrier function of the two groups were compared. At the same time, regression analysis was carried out on possible influencing factors of the experimental group.

  Results  It showed a significant difference in D-lactic acid since its level was higher in experimental group than the control group (P < 0.05); lipopolysaccharides and diamine oxidase were higher in experimental group, but there were no significant between-group differences (P>0.05). The multiple regression analysis showed that non-acute ischemic stroke combined with hypertension, diabetes and renal insufficiency and malnutrition were risk factors of intestinal barrier dysfunction.

  Conclusion  Intestinal barrier dysfunction in patients with non-acute ischemic stroke mainly manifested as the elevation of blood D-lactate level. Active intervention of related risk factors can improve the intestinal barrier function and enhance the comprehensive prevention and treatment ability of the disease.